Adjust the slider to show how you'd split your country's finite resources between the military (weapons and armed forces) and clinical trials to cure and treat disease.
Current clinical trial costs are 82x times higher than pragmatic trial alternatives.
Traditional clinical trials cost $41K per participant, exceeding median annual income in many countries.
The average cost to develop a new drug is $2.6B, reflected in pharmaceutical pricing.
Regulatory delays contribute to an estimated 21,000-120,000 preventable deaths per decade.
Current trial eligibility criteria exclude 86.1% of patients with the condition being studied.
95% of known diseases lack FDA-approved treatments, with research concentrated on the remaining 5%.
The average time from discovery to widespread clinical adoption is 14 years.
An estimated 45.1B potential treatment combinations remain untested with current methodologies.
Approximately 2.4B people worldwide suffer from diseases with inadequate treatment options.
No major disease has been cured in over 44 years, highlighting the need for new research paradigms.
HUMANITY SPENDS
THAN CURING ALL DISEASES COMBINED
That tiny line on the left? That's ALL of modern medicine.
You cannot have "diminishing returns" when you haven't even started.
The 9.5M figure above only counts single drugs against diseases. Modern medicine increasingly uses combination therapies (standard in oncology, HIV, cardiology).
Note: We use the conservative 9.5M figure in our main calculations because single-drug trials are more straightforward. But the combination therapy space shows the true scale of unexplored medicine.
Clinical trials are how we discover which treatments work for which diseases. At current trial capacity, we find first effective treatments for only ~15 diseases per year.
Pragmatic trials cost ~44× less than traditional trials. This funding enables 12× more trials = ~180 first treatments per year.
Critics argue: "Just funding more trials won't proportionally increase discoveries - we've picked the low-hanging fruit."
This is wrong for six reasons:
Diminishing returns apply to repeated attempts at the same problem. We're proposing to attempt problems we've never tried.
This timeline shows how soon we could find a first treatment for all 6,650 untreated diseases. Under the status quo (~15 new treatments/year), it takes 443 years. With increased pragmatic trial funding, we can accelerate discovery dramatically.
Treatments exist. Safe compounds exist. Patients are waiting.
The missing ingredient is trial capacity. That's a logistics problem, not a scientific frontier.
Adjust the slider to show how you'd split your country's finite resources between the military (weapons and armed forces) and clinical trials to cure and treat disease.
$27.2B/year scales trial capacity 12X, achieving 246 years of progress in 20
Through a 212-year average timeline shift: 12× trial capacity + eliminating 8.2-year regulatory delays
Highest ROI Action in History
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